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Phentermine Hydrochloride – How it Works

Friday, August 20th, 2010

Phentermine activates humans’ both motor and mental activity and motivates your brain by sending signals “Stop eating”, “Lose Weight.”

Activity caused by one pill of Phentermine is similar to a few cups of good coffee. Your laziness disappears, your attention is focused, you feel happy and full of energy, you are ready to create and build. This is how you can describe the way Phentermine works.

How do you refill this extra energy? Instead of eating, because your appetite is suppressed, your body receives necessary nutrients and energy from fat. As a result, your fat is “burned”, and your weight is reduced.

Phentermine is a Catalyst of The Stress

Phentermine is a drug taken orally. After it gets inside your body, Phentermine Hydrochloride starts neurochemical reactions by releasing stress hormones Dopamine and Noradrenaline. These hormones regulate your mood and behavior in stressful situations.

Phentermine wakes up the natural reaction of your body called “Fight or Flight”. This is your survival mechanism that runs in dangerous and stressful situations. This reaction disables the functions of your body that are not important at this moment of time and activates those functions that are necessary for survival:

- Increased physical activity and muscle tone;
- Decreased appetite (Noradrenaline increases the amount of sugar in the blood, and your brain thinks that you are full);
- Slowed down digestive system.

After taking Phentermine, your body is actively working the whole day, and you don’t want to eat that much.

Phentermine Weight Loss Due Negative Energy Balance

Phentermine treatment causes weight loss due to your body’s state of negative energy balance. How does it work? Let’s see:

Energy Balance in the Body

The amount of energy intake should be equal to the energy consumption in order to maintain a stable weight and normal body functioning.

Otherwise, a deficiency or excess of energy occurs, and this energy will be converted into an extra layer of fat, saved for a rainy day.

This is the formula of energy balance:

Energy intake – energy consumption = variation in energy storage.

If this value is zero your weight will remain stable. Any positive value (excess of energy consumption) will increase energy storage that is your body weight.
With a negative energy balance your energy consumption will exceed the amount of calories absorbed. Theoretically, this means the consumption of body fat since all the excess energy is stored in fat.

For example, if your daily energy deficit is about 500 calories, your body weight should low down to about half a kilogram (or vice versa) per a week.

Basal Metabolic Rate

Basal metabolism is the minimum amount of energy required for sustaining the life of an organism in a state of rest (in the morning, while lying, on an empty stomach, in a thermal comfort).

Numerous basal metabolic rate studies have revealed that the rate of basal metabolism for men equals 1 kcal per 1 kg of body weight per hour, and for women (who have less muscle mass) it is 0.9 kcal per 1 kg of body weight per hour. Let’s make a rough calculation:

D = M x 24 x B
D is the daily basal metabolism in kilocalories;
24 is the amount of hours the day is divided into;
M is normal body weight in kilograms;
B is the basic metabolic rate per hour in kilocalories per 1 kilogram.

For example, the daily basal metabolism of a man with normal body weight of 70 kg will be:

D = 70 x 24 x 1
D = 70 x 24
D = 1680 kcal a day

You can convert kg to lbs here

Thus, the approximate value of a normal daily metabolic rate for men with normal body weight of 70 kg is 1700 kcal. A similar calculation of this value for women with normal body weight of 70 kg is 1500 kcal. Such a difference is mainly caused by the fact that most women have less muscle mass than men.

When we workout, most of the energy consumption occurs at the expense of skeletal muscles. These muscles are the main users of energy ingested with food and they should burn up to 90% of it. This is why you can see natural normalization of weight when you apply physical exercises and power loads in order to lose weight. They are powerful activators of metabolism and they may reduce the amount of energy stored in our body as fat.

If you lead a sedentary lifestyle typical for a big number of people, your muscles will burn 26% of energy while you are working out, the same amount they burn when your body is at rest. This causes the reduction in the intensity of all the processes of energy conversion and accumulation as fat. With regular exercising such as brisk walking, gymnastics, aerobics, and jogging, your energy consumption will greatly increase during exercises and, to a lesser extent, due to an increased level of basal metabolic rate.

How Does Phentermine Change Your Energy Balance?

When you are taking Phentermine, you start the neurochemical reaction in your body. This reaction secretes chemicals known as neurotransmitters that affect our body in various ways.

They give us more energy, a sense of cheerfulness, and make us do more physical activities. As we exercise, we start to consume more energy.

These chemicals also raise our blood sugar levels. As a result, we get a feeling of satiety even if we haven’t eaten anything. They inhibit our gastrointestinal tract by giving us a feeling of fullness.

High physical activity and the reduced need of our body for calories due to a false sense of satiety increases fat consumption. And this reduces our weight.

Phentermine starts the reaction of the body known among doctors as “fight or flight”. This is the common response of our body under anxiety and stress. Our physical activity along with energy consumption is increased by several times. Phentermine stimulates our body’s response so as to lose more weight.

Being in fight or flight response, we don’t want to eat that much. Our appetite is suppressed thanks to Phentermine, as we are in a made-up stressful situation. Besides this, our metabolism is increased and our rate of energy expenditure is also increased because we are ready to run, jump and even apply our superhuman powers.

As you have guessed, our body burns more calories that would otherwise be stored as fat. Thus our energy balance is changed to achieve better weight loss results.

Ashley Reis from Cheyenne, WM, USA – Phentermine user:

Phentermine Diet, Exercises and Eating Behaviors

Which diet should be followed while taking Phentermine?

Diet should be selected individually based on body mass index and other factors. Consult with a nutritionist for the appointment of an individual program.

from 1500 to 1800 calories per day for men
and from 1000 to 1200 calories per day for women.

What exercises?

At least 3 times a week for 30 minutes each session. Burn time of 300 calories. Walking, smooth, aerobics, cycling. Exercises should bring joy to the patient.
Indoors and outdoors depending on weather conditions.
Also use a daily activity for yourself – use the stairs instead of elevators, walk from the parking lot more and so on.

Changing eating behavior

Learn to understand – what, when and why you eat. Let your dietitian will teach you that. Ask the support of friends and family members.
food in social situations.
serving size.
awareness of eating.
eat breakfast and eat slowly.

Indications for Phentermine Therapy

In accordance with the drug summary, included in each package of Phentermine and Adipex-P, these medications are designed for obesity treatment (i.e. Body Mass Index (BMI)>30 or >27 if other risk factors are also present), and, among others, for maintaining the achieved weight loss results if a patient follows a low-calorie diet plan. Besides the common indications, weight loss treatment with these drugs may be recommended if:
1. The risk factor is present.
2. Weight loss attempts are ineffective due to lifestyle changes only.
3. It is the patient’s will (in case he understands the mechanism of drug action and agrees to stay under medical supervision).

Indications to Stop Phentermine Therapy

Many patients ask doctors to prescribe them medications for body weight loss, but they would like to take them for a short period of time, only at the beginning of their weight loss plan. Still, clinical trials of fen-phen use have shown that its effect usually quickly disappears after drug discontinuation. It is very important to pay the patient’s attention at the necessity of a long-term treatment when discussing the drug therapy of obesity. A short-term treatment can worsen the patient’s misconception, typical for many people, that after losing weight you don’t need to make any efforts to maintain your reduced body weight. It is more correctly to consider obesity being a stable metabolic disorder that often progresses with age, as well as arterial hypertension, high cholesterol (hyperlipidemia), and diabetes mellitus (DM). From this point of view, all medications can only supplement the lifestyle changes. It is needed to take them constantly, while a patient intends to maintain weight loss. Sometimes patients take drugs only at times when it is difficult for them to comply with their diet plan and physical activities (e.g. during holidays, in winter, when stressed). The effectiveness of this approach has not been studied yet. Sometimes, it is possible to reduce the medication dosage taken for several years up to cancelling. But usually indications for drug treatment are maintained for the lifetime.